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KMID : 0617319940040010053
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Journal of Pharmacetical Sceiences Ewha Womans University
1994 Volume.4 No. 1 p.53 ~ p.62
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Rheological Characteristics of Lipiodol-Anticancer Suspensions Containing Aluminum Monostearate
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Abstract
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Lipiodol-anticancer suspensions containing fluorouracil, tegafur, mitomycin C, methotrexate, or adriamycin were prepared by Shinohara method using aluminum monostearate as a dispersing stabilizer. Lipiodol-suspension showed thixotropic property when the concentration of aluminum monostearate was above 2%. Observed thixotropic area which reflects the extent of thixotropic breakdown indicated that the thixotropic property of Lipiodol-suspensions maintained for six weeks in a refrigerator(4C). Lipiodol-anticancer suspensions containing 2% aluminum monostearate maintained a more stable suspension system compared with simple mixtures and Lipiodol-anticancer suspensions without aluminum monostearate. As the concentration of aluminum monostearate increased, the drug release from Lipiodol-anticancer suspensions was more retarded.
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